Release date: December 31, 2007
Available for credit through: December 31, 2008

Program Description

The issue of generic drug substitution is complex and often poorly understood by physicians and pharmacists. Although the FDA requires that two drugs are similar as demonstrated by bioequivalence data, therapeutic equivalence (or therapeutic effectiveness) and bioequivalence are not necessarily the same. In the case of antiepileptic drugs (AEDs), the therapeutic range over which they are effective may be narrow and, although generic substitution of AEDs may be appropriate for some patients with epilepsy, it may represent suboptimal care for others. There may be seizure recurrence or an increase in side effects with the use of generic drugs. In these patients, potential cost savings of generic AEDs must be weighed carefully against potential additional medical costs, such as extra office visits, emergency room visits, and hospitalizations. This program will give an overview of these and other important issues associated with generic substitution of AEDs.

Accreditation

ArcMesa Educators is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. ArcMesa Educators designates this educational activity for a maximum of 1 AMA PRA Category 1 creditTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ACPEArcMesa Educators is accredited by the Accreditation Council for Pharmacy Education as a Provider of continuing pharmacy education. (UPN 200-000-07-004-H01-P). Pharmacists will receive 1 contact hour (0.1 CEU) for successful completion of this activity.

ArcMesa Educators is an approved provider of continuing education in nursing by the ASNA, an accredited approver by the ANCC Commission on Accreditation. Nurses will receive 1 contact hour for successful completion of this activity.

Target Audience

This program is designed specifically for Pharmacists, Physicians, Physician Assistants, Nurse Practitioners, and Registered Nurses who treat patients with epilepsy.

Educational Objectives

At the conclusion of this activity, participants will be able to:

(Neurologists, Pharmacists, Physician Assistants and Nurses)

  • Describe evidence that generic and proprietary antiepileptic drugs may differ in therapeutic effectiveness

(Neurologist, Physician Assistants and Nurses)

  • Evaluate factors, including overall cost burden, that influence treatment choices in managing patients with epilepsy
  • Identify patients with epilepsy who may not be appropriate candidates for treatment with generic antiepileptic drugs

(Pharmacists)

  • Identify potential additional medical costs associated with generic antiepileptic drugs
  • Compare potential cost savings of generic antiepileptic drugs to potential additional medical costs

There are no fees to participate in this activity. A certificate of completion for physicians and a statement of credit for pharmacists may be printed out after viewing the program and submitting your post-test and evaluation form.

Disclosure Policy

It is the policy of ArcMesa Educators to ensure balance, independence, objectivity, and scientific rigor in all its educational activities. All faculty/authors are expected to disclose any relevant financial relationships they may have with commercial interests in relation to this activity. These relationships, along with the educational content of this program, have been reviewed and any potential conflicts of interest have been resolved to the satisfaction of ArcMesa Educators.

Staff Disclosure Declarations

The employees of ArcMesa Educators have no financial relationships to disclose.

Faculty Disclosure Declarations

John M. Pellock, MD – Advisory Board, Consultant, Lecturer and Researcher for the following: Abbott Laboratories, Cephalon, Eisai, GlaxoSmithKline, MedPointe, Novartis, OrthoMcNeil, Ovation, Pfizer, Questcor, Schwarz Pharma, UCB, and Valeant; Consultant and Lecturer for the following: Accorda, AstraZeneca, Aventis, and CoSensys; Advisory Board and Consultant for: Marinus Pharmaceuticals

Andrew J. Pultz, Jr, PharmD, RPh – Nothing to disclose

Duke Duguay, PhD (Medical Writer) – Nothing to disclose

Disclaimer

©2007 ArcMesa Educators / CMEdiscovery.com. All rights reserved. None of the contents may be reproduced in any form without prior written permission from ArcMesa Educators.

The views and opinions expressed in this activity are those of the faculty. They do not reflect the views of Abbott Laboratories Inc., any other manufacturer of pharmaceuticals, or ArcMesa Educators.

The recommendations made in this program are based upon a combination of randomized clinical trials, current guidelines, and the clinical practice experience of the participating panelists. Any medications, diagnostic procedures or treatments discussed by the panelists should not be utilized without evaluation of their patient's conditions. Participants are urged to consult the full prescribing information on any drug mentioned in this activity for recommended dosage, indications, contraindications, warnings, precautions, and adverse effects before prescribing any medication.

 

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John M. Pellock, MD

John M. Pellock, MD
Program Chair, Professor and Chairman
Division of Child Neurology
Virginia Commonwealth University


John M. Pellock, MD

Andrew J. Pultz, Jr, PharmD, RPh
Specialty Practice Pharmacist
The Ohio State University Medical Center


CMEdiscovery.com

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